摘要: Tricyclic antidepressants have been used to manage pain for several decades, and are superior treatments some patients suffering from neuropathic pain. Unfortunately, older dose-limiting side effects that can lead drug intolerance. The most common anticholinergic effects, although experience sexual dysfunction. Cognitive impairment, sedation, orthostatic hypotension also relatively common. Taking an overdose of tricyclic be lethal in overdose. Several weeks therapy may required before antinociception occurs, but optimal doses appear the effective treatment pain; this is supported by systematic reviews comparing them with other agents. Newer medications such as atypical anticonvulsants overtaking antidepressants, they should not overlooked important options management
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Sally L Collins, R.Andrew Moore, Henry J McQuay, Philip Wiffen, Antidepressants and anticonvulsants for diabetic neuropathy and postherpetic neuralgia: a quantitative systematic review. Journal of Pain and Symptom Management. ,vol. 20, pp. 449- 458 ,(2000) , 10.1016/S0885-3924(00)00218-9
F Coluzzi, F Paoletti, C Mattia, A Boanelli, New antidepressants in the treatment of neuropathic pain. A review. Minerva Anestesiologica. ,vol. 68, pp. 105- 114 ,(2002)
Klaus Bielefeldt, Noriyuki Ozaki, Carol Whiteis, Gerald F. Gebhart, Amitriptyline inhibits voltage-sensitive sodium currents in rat gastric sensory neurons. Digestive Diseases and Sciences. ,vol. 47, pp. 959- 966 ,(2002) , 10.1023/A:1015061317793
Ganesan L. Kamatchi, Joseph J. Pancrazio, Carl Lynch, Amy K. Roscoe, Inhibition of Neuronal Na+ Channels by Antidepressant Drugs Journal of Pharmacology and Experimental Therapeutics. ,vol. 284, pp. 208- 214 ,(1998)
Søren H. Sindrup, Lars F. Gram, Kim Brøsen, Ole Eshøj, Erik F. Mogensen, The selective serotonin reuptake inhibitor paroxetine is effective in the treatment of diabetic neuropathy symptoms Pain. ,vol. 42, pp. 135- 144 ,(1990) , 10.1016/0304-3959(90)91157-E
Gerrit Kiefer, Wilhelm Fischer, Thomas Feuerstein, Effects of amitriptyline, amitriptylinoxide, doxepine and clozapine on N-methyl-D-aspartate-evoked release of [3H]-acetylcholine in rat caudatoputamen. Drug Research. ,vol. 49, pp. 820- 823 ,(2011) , 10.1055/S-0031-1300508
Shaul Schreiber, Avi Bleich, Chaim G. Pick, Venlafaxine and mirtazapine: different mechanisms of antidepressant action, common opioid-mediated antinociceptive effects--a possible opioid involvement in severe depression? Journal of Molecular Neuroscience. ,vol. 18, pp. 143- 149 ,(2002) , 10.1385/JMN:18:1-2:143
Richard H. Rho, Randall P. Brewer, Tim J. Lamer, Peter R. Wilson, Complex Regional Pain Syndrome Mayo Clinic Proceedings. ,vol. 77, pp. 174- 180 ,(2002) , 10.4065/77.2.174
James C. Eisenach, G. F. Gebhart, Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats Anesthesiology. ,vol. 83, pp. 1046- 1054 ,(1995) , 10.1097/00000542-199511000-00018
Rita B. Messing, Loy D. Lytle, Serotonin-containing neurons: their possible role in pain and analgesia. Pain. ,vol. 4, pp. 1- 21 ,(1977) , 10.1016/0304-3959(77)90083-5