Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis.

摘要: Advanced glycation end-product (AGE)-damaged IgG occurs as a result of hyperglycemia and/or oxidative stress. Autoantibodies to IgG-AGE were previously demonstrated in patients with severe, longstanding rheumatoid arthritis (RA). We investigated whether and anti-IgG-AGE antibodies present early the course RA other inflammatory arthropathies. prospectively followed cohort 238 duration less than 1 year. Patients evaluated clinically serologically, radiographs obtained at initial 1-year visits. Sera assayed for by enzyme-linked immunosorbent assay (ELISA). Rheumatoid factor (RF) was determined nephelometry ELISA. Of all patients, 29% had RF-positive RA, 15% RF-negative 18% spondyloarthropathy, 38% undifferentiated arthritis. 19% similar amount frequency groups. elevated levels significantly higher markers C-reactive protein erythrocyte sedimentation rate, but there no correlation blood glucose levels. Overall, 27% IgM antibodies. These highly associated RFs (P < 0.0001) swollen joint count 0.01). In onset arthritis, damaged AGE detected patient The ability make antibodies, however, restricted subset more active disease. persistence response specific transient spondyloarthropathy who initially found be positive