Immunogold labeling of cerebrovascular and neuritic plaque amyloid fibrils in Alzheimer's disease with an anti-β protein monoclonal antibody

摘要: A monoclonal antibody raised to a synthetic peptide consisting of residues 8 17 the amyloid beta protein Alzheimer's disease was employed for immunogold electron microscopic studies on fibrils cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed specific gold labeling these structures. This provides ultrastructural evidence that is intimately associated with fibril. With previous chemical evidence, observation supports concentration it an intrinsic component