Inhibition of Transforming Growth Factor‐β (TGF‐β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer
作者： Amber A. Bokhari , Viqar Syed
DOI: 10.1002/JCB.25138
关键词:
摘要: Transforming growth factor-β (TGF-β), regulates cell proliferation, angiogenesis, metastasis, and is an inducer of epithelial-mesenchymal transition (EMT). Cancer cells exhibit activated TGF-β/SMAD signaling pathway its inhibition attractive strategy for cancer treatment. The Chinese Herbs Scutellaria baicalensis (SB) Fritillaria cirrhosa (FC) have been shown to be beneficial patients, but the mechanisms by which extracts two herbs elicit effects are unclear. In this study, we used human endometrial assess anticancer efficacy SB FC on TGF-β components. treatment resulted in a significant decrease expression isoforms, receptors, SMADs. Both effectively inhibited basal TGF-β1-induced proliferation invasion, was accompanied with abrogation Snail, Slug, matrix metalloproteinases (MMPs), αvβ3 integrin, focal adhesion kinase (FAK), p-FAK expression. An inhibitor TGF-βRI blocked invasion significantly diminished antitumor FC. These results suggest that block downregulating pathway.
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