Dysregulation of long non-coding RNAs in mouse models of localization-related epilepsy

摘要: Genome-wide profiling has revealed that eukaryotic genomes are transcribed into numerous non-coding RNAs. In particular, long RNAs (lncRNAs) have been implicated in various human diseases due to their biochemical and functional diversity. Epileptic disorders characterized by dysregulation of epigenetic regulatory mechanisms, recent studies identified several lncRNAs involved neural development network function. However, comprehensive chronic epilepsy lacking. this study, microarray analysis was performed obtain the expression profile dysregulated pilocarpine kainate models, two models temporal lobe commonly used for studying epileptic mechanisms. Total 4622 were analyzed: 384 significantly model, 279 model compared with control mice (≥3.0-fold, p < 0.05). Among these, 54 14 lncRNAs, respectively, had adjacent protein-coding genes whose expressions also (≥2.0-fold, Majority these pairs shared same direction dysregulation. For selected gene-lncRNA pairs, significant Gene Ontology terms embryonic appendage morphogenesis neuron differentiation. This first study comprehensively identify different will likely provide a novel insight developing lncRNA therapeutics.