摘要: Prostate cancer is a significant public health problem. There are 10 000 cases per year in England and Wales, 8000 deaths1. In the USA, it most common malignancy second cause of deaths2, with 132000 34000 deaths2. Furthermore, incidence increasing by 10–20% every 5 years4. Conversely, histological evidence asymptomatic prostate found frequently at autopsy5. Therefore, seems that large proportion men harbour disease which will remain asymptomatic, whilst, others, progresses to substantial morbidity mortality. One main goals research into genetics identify those lesions progress clinically disease.
springer.com
sci-hub.st 参考文章(91)
Bob S. Carter, G. Steven Bova, Terri H. Beaty, Gary D. Steinberg, Barton Childs, William B. Isaacs, Patrick C. Walsh, Hereditary Prostate Cancer: Epidemiologic and Clinical Features Journal of Urology. ,vol. 150, pp. 797- 802 ,(1993) , 10.1016/S0022-5347(17)35617-3
Jacques Estève, Michel Coleman, Trends in cancer incidence and mortality IARC scientific publications. pp. 1- 806 ,(1993) , 10.3109/9780415874984-2
Gustave Malécot, Les mathématiques de l'hérédité Masson. ,(1948)
M E Kaighn, Y Ohnuki, K S Narayan, L W Jones, J F Lechner, Establishment and characterization of a human prostatic carcinoma cell line (PC-3). Investigative urology. ,vol. 17, pp. 16- 23 ,(1979)
E. Steliarova-Foucher, M. Laversanne, J. Ferlay, D. Forman, S. Antoni, Freddie Ian Bray, C. Gombe Mbalawa, B. Kohler, M. Piñeros, D. H. Brewster, I. Soerjomataram, R. Swaminathan, Cancer Incidence in Five Continents ,(1997)
Alan W. Partin, Brent Treiger, John T. Isaacs, Donald S. Coffey, Early Cell Motility Changes Associated with an Increase in Metastatic Ability in Rat Prostatic Cancer Cells Transfected with the v-Harvey-ras Oncogene Cancer Research. ,vol. 48, pp. 6050- 6053 ,(1988)
Nathalie G. Bérubé, Marsha D. Speevak, Mario Chevrette, Suppression of tumorigenicity of human prostate cancer cells by introduction of human chromosome del(12)(q13). Cancer Research. ,vol. 54, pp. 3077- 3081 ,(1994)
G. Morganti, L. Gianferrari, A. Cresseri, G. Arrigoni, G. Lovati, RECHERCHES CLINICO-STATISTIQUES ET GÉNÉTIQUES SUR LES NÉOPLASIES DE LA PROSTATE Human Heredity. ,vol. 6, pp. 304- 305 ,(1956) , 10.1159/000150844
Shawn M. Brisbay, Timothy J. McDonnell, Patricia Troncoso, Leland W. K. Chung, Martin L. Campbell, Jer-Tsong Hsieh, Shi-Ming Tu, Christopher Logothetis, Expression of the Protooncogene bcl-2 in the Prostate and Its Association with Emergence of Androgen-independent Prostate Cancer Cancer Research. ,vol. 52, pp. 6940- 6944 ,(1992)
Mauro F. Santibáñez-Koref, Karen J. Tricker, Alison Condie, Derek Crowther, Jillian M. Birch, D. Gareth R. Evans, Ann L. Hartley, Jane Prosser, Alan W. Craft, Eileen Thompson, John Martin, Martin Harris, Patricia H. Morris Jones, Osborne B. Eden, Aine Binchy, Anna M. Kelsey, Jillian R. Mann, Erika L. D. Mitchell, Prevalence and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Research. ,vol. 54, pp. 1298- 1304 ,(1994)