Transition‐Metal‐Catalyzed Carbonylative Domino Reactions

摘要: ‘‘Sustainable development’’ has become one of the hottest terms in twenty-first century. Of particular relevance organic chemistry are reaction efficiency and avoidance waste generation. With regard to sustainability, methodologies based on domino reactions, including multicomponent a highly efficient strategy synthesize complicated compounds. Domino reactions defined as processes two or more bond-forming under identical conditions, which subsequent transformations take place at functionalities that obtained previous transformations. Using compounds can be relatively easily prepared from simple substrates. No tedious preparation intermediates purification needed, most energy-consuming waste-generating steps synthesis [1]. One prominent example is Knoevenagel/hetero-Diels–Alder reaction, dihydropyrans could straightforwardly synthesized readily available starting materials [2]. Transition-metal catalysts play an ever-increasing important role modern [3]. Numerous transition-metal-catalyzed coupling have been developed applied total natural products, such Suzuki theNegishi theHeck andmany others [4]. Interestingly, power transition-metal even visible area where palladium walking show value transition metals bond formations. Carbonylation interesting with both industrial academic research [5]. In these carbonmonoxide (CO) used cheapest C1 sources. By introducing CO units into parent molecules, carbonyl-containing products prepared, further modified yield chemicals for synthesis. Following definition we realized our surprise all carbonylative belong least C–C bonds were formed same conditions.