Isoproterenol exacerbates hyperglycemia and modulates chromium distribution in mice fed with a high fat diet.

摘要: Abstract Background and purpose Isoproterenol (ISO), a nonselective β-adrenoceptor agonist for treating bradycardia asthma, has been proposed to raise blood glucose level. Little is known regarding the relationship between ISO treatment, induced chromium (Cr) redistribution, changes in metabolism. We aimed characterize effects of single dose on homeostasis Cr level an obesity mouse model. Methods Mice (C57BL6/j strain) were first fed continuous period 12 weeks with either high fat diet (HFD), develop animal model, or standard (SD), lean model as controls. These groups each separated into two subgroups receive saline (control). measured vivo their metabolic parameters, fasting level, area under curve (AUC) time profile, insulin sensitivity index, distribution. Results After ISO, SD-fed mice had slightly higher levels compared SD controls, when was 30 60 min after injection. By contrast, ISO-treated HFD-fed significantly AUC during entire 120 min following one administration HFD control group. Additionally, they substantially lower HOMA-IR whereas remained unchanged. The bones liver decreased, loss through urinary excretion elevated. Conclusion results demonstrated that exacerbated hyperglycemic syndrome net negative balance result increased excretion, leading mobilization not desirable overcome hyperglycemia.