Jiang Tang Xiao Ke Granule, a Classic Chinese Herbal Formula, Improves the Effect of Metformin on Lipid and Glucose Metabolism in Diabetic Mice.
作者： Yi Zhang , Hong An , Si-Yuan Pan , Dan-Dan Zhao , Jia-Cheng Zuo
DOI: 10.1155/2016/1592731
关键词:
摘要: In the present study, hypoglycemic, hypolipidemic, and antioxidative effects of metformin (MET) combined with Jiang Tang Xiao Ke (JTXK) granule derived from “Di Huang Tang” were evaluated in mice type 2 diabetes mellitus (DM) induced by high-fat diet/streptozotocin. DM orally treated MET (0.19 g/kg) either alone or different doses (1.75, 3.5, 7 g/kg) JTXK for 4 weeks. Results showed that serum hepatic glucose, lipids, oxidative stress levels elevated mice, when compared normal mice. treatment decreased FBG glucagon Combination 3.5 g/kg increased hypoglycemia insulin sensitivity at weeks alone. However, neither nor MET/JTXK could completely reverse hyperglycemia enhanced triglyceride (TG) lipid-lowering effect a dose-dependent manner 1.75 improved hepatoprotective Synergistic combination on antioxidant was also found
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