Fatigue symptoms associated with COVID-19 in convalescent or recovered COVID-19 patients; a systematic review and meta-analysis

摘要: Background The prevalence and prognosis of post-acute stage SARS-CoV-2 infection fatigue symptoms remain largely unknown. Aims We performed a systematic review to evaluate the in post-recovery from infection. Method Medline, Embase, PsycINFO, CINAHL, Web Science, Scopus, trial registries, Cochrane Central Register Controlled Trials Google Scholar were searched for studies on samples that recovered PCR diagnosed COVID-19. Meta-analyses conducted separately each recruitment setting. Results We identified 39 with 8825 patients Post-COVID-19 self-report was higher compared healthy controls (RR = 3.688, 95%CI [2.502, 5.436], p < 0.001). Over 50% discharged inpatient care reported during first (ER 0.517, [0.278, 0.749]) second month following recovery 0.527, [0.337, 0.709]). 10% community post-recovery. Patient setting moderated association between COVID-19 (R2 0.12, Female gender associated greater (OR =1.782, [1.531, 2.870]). Patients recruited through social media had above 90% across multiple time points. Fatigue highest Europe. Conclusion Fatigue is symptom functional challenges which could have economic impacts. Developing long-term planning management amongst beyond acute stages essential optimizing patient public health outcomes.