Spontaneous Retinal Activity Is Tonic and Does Not Drive Tectal Activity during Activity-Dependent Refinement in Regeneration

摘要: During development, waves of activity periodically spread across retina to produce correlated that is thought drive activity-dependent ordering in optic fibers. We asked whether similar are produced the adult goldfish during refinement by regenerating Dual-electrode recordings spontaneous were made at different distances but revealed no evidence retinal normal or regeneration. Retinal was tonic and lacked episodic bursting associated with waves. Cross-correlation analysis showed normally restricted near neighbors (typically seen 100–200 μm absent >500 μm) not altered The only change regeneration a twofold reduction ganglion cell firing rates. Because known be sufficient generate goldfish, we examined its effect on tectal activity. In fish, acutely eliminating TTX rapidly reduced unit >90%. Surprisingly, 4–6 weeks, had detectable Similar results obtained from torus longitudinalis. After 3 months, again highly dependent ongoing conclude drives cells fish after refinement. implications these for role presynaptic considered.