Genetics of progressive renal failure in diabetic kidney disease

摘要: Genetics of progressive renal failure in diabetic kidney disease Diabetic is a microvascular complication that observed minority patients with long-standing hyperglycemia. nephropathy (DN) associated shortened patient survival, severe morbidity, and increased health care costs. Unfortunately, the incidence rates DN continue to increase Western societies, now most common reported cause end-stage developed nations. results from complex interplay between inherited environmental factors. This article reviews data support an basis for susceptibility by summarizing familial aggregation studies, genome-wide linkage, population-based association analyses nondiabetic disease. Recent evidence linking genes involved regulation endothelial function genetic predisposition albuminuria presented. The integration carefully designed linkage studies gene expression experiments human animal models appear offer great promise detecting molecular mechanisms underlying DN.