18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

摘要: Progressive supranuclear palsy (PSP) is characterized by deposition of straight filament tau aggregates in the grey matter (GM) deep nuclei and cerebellum. We examined relationship between pathology (assessed via 18F-AV1451 PET) multimodal MRI imaging using GM volume, cortical thickness (CTh), diffusion tensor (DTI). Twenty-three people with clinically probable PSP-Richardson’s syndrome (age 68.8 ± 5.8 years, 39% female) 23 controls underwent structural 3 T brain including DTI. Twenty-one patients also had PET imaging. Voxelwise volume-based morphometry, surface-based DTI correlations were performed binding typical PSP regions interest (putamen, thalamus dentate cerebellum). Clinical impairment was assessed relation to different modalities. subjects showed volume loss frontotemporal regions, basal ganglia, midbrain, cerebellum (FDR-corrected p < 0.05), reduced CTh left entorhinal fusiform gyrus (p < 0.001) as well changes corpus callosum, internal capsule, superior longitudinal fasciculus (FWE-corrected p < 0.05). In PSP, higher correlated frontal motor tracts, thinning parietooccipital areas. Cognitive related decreased pallidum, alteration callosum cingulum. This cross-sectional study demonstrates an association vivo proxy measures white degeneration PSP. adds present literature about complex interplay protein deposition.