Melanocortin signaling in the CNS directly regulates circulating cholesterol.

摘要: Cholesterol circulates in the blood association with triglycerides and other lipids, elevated low-density lipoprotein cholesterol carries a risk for metabolic cardiovascular disorders, whereas high-density (HDL) is thought to be beneficial. Circulating balance among dietary absorption, hepatic synthesis secretion, metabolism of lipoproteins by various tissues. We found that CNS also an important regulator rodents. Inhibiting brain's melanocortin system pharmacological, genetic or endocrine mechanisms increased circulating HDL reducing its uptake liver independent food intake body weight. Our data suggest neural circuit brain directly involved control liver.