Transforming growth factor-β1 promotes breast cancer metastasis by downregulating miR-196a-3p expression.

摘要: // Yan Chen 1, 2, * , Shai Huang Bo Wu 3, Jiankai Fang 2 Minsheng Zhu Li Sun 4 Lifeng Zhang 1 Yongsheng 5 Maomin Lingling Guo and Shouli Wang 6, 7 Department of Surgery, The First Affiliated Hospital Soochow University, Suzhou 215006, China Pathology, School Biology & Basic Medical Sciences, 215123, 3 People’s Sihong County, 223900, Jiangsu Province, Laboratory Animal Research Center, University Medicine, Second 215004, 6 Molecular County Hospital, Key Tumor Microenvironment These authors have contributed equally to this work Correspondence to: Wang, email: wangsoly112@hotmail.com Guo, guo-lingling@126.com Keywords: microRNA, miR-196a-3p, transforming growth factor-β1, breast cancer Received: December 12, 2016     Accepted: February 23, 2017     Published: March 17, 2017 ABSTRACT Transforming factor-β1 is considered a key contributor the progression cancer. MicroRNAs are important factors in development many malignancies. In present study, upon studies cell lines tissues, we showed that microRNA -196a-3p decreased by cells associated with progression. We identified neuropilin-2 as target gene it regulated factor-β1. Moreover, factor-β1-mediated inhibition activation neuropilin-2were required for factor-β1-induced migration invasion cells. addition, expression was suppressed tumors, particularly triple-negative cancers. Collectively, our findings strongly indicate predictive biomarker metastasis patient survival potential therapeutic metastatic