Intermolecular Reactions of Pyridyl Radicals with Olefins via Photoredox Catalysis.
作者： Ciaran P Seath , Nathan T Jui , None
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摘要: Pyridines are valuable motifs in a number of bioactive and functional molecules. The chemoselective functionalization these structures from stable widely available starting materials is meaningful goal. We have demonstrated selective formation pyridyl radicals at any position (2-, 3-, 4-pyridyl), through the action reducing photoredox catalyst. These readily engage alkenes to deliver high-value products. Alteration reaction medium has enabled use diverse range alkene subtypes highly divergent manner. 1 Introduction 2 Minisci-Type Pyridine Alkylation 3 An Alternate Approach – Reductive Radical Formation 4 Conjugate Addition Pyridyl Radicals 5 Radical Hydroarylation Neutral Rich Olefins 6 Solvent-Based Chemoselectivity 7 Summary Outlook
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