1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.
作者： Sergio Valente , Daniela Trisciuoglio , Teresa De Luca , Angela Nebbioso , Donatella Labella
DOI: 10.1021/JM500303U
关键词:
摘要: We describe 1,3,4-oxadiazole-containing hydroxamates (2) and 2-aminoanilides (3) as histone deacetylase inhibitors. Among them, 2t, 2x, 3i were the most potent selective against HDAC1. In U937 leukemia cells, 2t was more than SAHA in inducing apoptosis, displayed cell differentiation with a potency similar to MS-275. several acute myeloid (AML) lines, well cells combination doxorubicin, showed higher antiproliferative effects SAHA.
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