A kinetic and thermodynamic study of fractional precipitation of paclitaxel from Taxus chinensis
作者： Chung-Gi Lee , Jin-Hyun Kim
DOI: 10.1016/J.PROCBIO.2017.05.016
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摘要: Abstract This study investigated the effect of precipitation time and temperature on efficiency fractional during purification paclitaxel. The kinetics thermodynamics this process were also analyzed. Fractional was carried out at different temperatures (−10, 4, 7, 8, 10 °C) highest yield obtained in shortest 4 °C. Johnson-Mehl-Avrami-Komolgorov (JMAK) equation applied to experimental data nucleation growth found take place simultaneously −10, 8 °C, while these processes occurred a consecutive manner 10 °C. In addition, transformation rate (rate constant k = 1.810 × 10 −5 min −1 ) 4 °C, suggesting that is ideal for precipitation. Analysis thermodynamic parameters confirmed exothermic, irreversible, spontaneous
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