Future of Sleep Research

摘要: There are many opportunities for the future of sleep and disorders research. is growing recognition public health significance disorders. new technological approaches that facilitate addressing major research questions. This article highlights a number current Several discussed in line with recent plan published by National Institutes Health In basic science area, there to address interaction between circadian systems. particularly so peripheral tissues metabolism. Many metabolic processes under control local clocks. Inadequate also leads insulin resistance enhanced appetite. need understand mechanisms this at fundamental level how interacts clock mechanisms. question overlaps another key area inquiry – functions sleep. Is only brain or does it have restorative function other organs? Two areas likely emphasis establishment personalized medicine comparative effectiveness (CER). The former envisages tailoring diagnosis treatment specific characteristics subgroups patients particular disorder rather than applying same approach all subjects. Subgroups will be identified based on clinical information, imaging, molecular signatures. basis these differences can due genetic, epigenetic, and/or environmental factors. While future, CER present. seeks determine optimal way diagnose treat lowest cost. Its focus real-world settings. Identification questions requires inputs from stakeholders physicians, healthcare providers, patients, policy makers, payors, etc. New study designs being developed important type Obstructive apnea has already been as high priority highly prevalent.