Antigen-presenting cells in human cutaneous leishmaniasis due to Leishmania major.

作者: A. M. ELHASSAN , A. GAAFAR , T. G. THEANDER

DOI: 10.1111/J.1365-2249.1995.TB05571.X

关键词:

摘要: In this study biopsies from skin lesions and draining lymph nodes of patients suffering cutaneous leishmaniasis caused by Leishmania major were examined immunohistochemistry, light electron microscopy to identify the types antigen-presenting cells (APC) their location. APC, identified morphologically expression specific cell markers, included Langerhans cells, macrophages, follicular dendritic interdigitating reticulum paracortex nodes. These expressed MHC class II antigens contained antigen. Since some keratinocytes endothelial also showed these characteristics, they may act as APC. By examining tissue samples it was possible follow probable route trafficking various inflammatory between lesion antigen containing found in epidermis, dermis regional We believe translocate epidermis dermis, where take up migrate There are intimately associated with paracortex, could be involved generation Leishmania-specific T memory cells. LFA-1-positive CD45RO phenotype lesion. Venular endothelium intercellular adhesion molecule-1 (ICAM-1), which is ligand for LFA-1. The migration lymphocytes vascular lumen site inflammation possibly a result interaction two molecules.

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