Disregulation of Autophagy in the Transgenerational Cc2d1a Mouse Model of Autism.
作者： Halime Dana , Keziban Korkmaz Bayramov , Nesrin Delibaşı , Reyhan Tahtasakal , Ruslan Bayramov
DOI: 10.1007/S12017-019-08579-X
关键词:
摘要: Autism spectrum disorder (ASD) is a heterogeneously childhood neurodevelopmental disorder, believed to be under development of various genetic and environmental factors. Autophagy related pathways have also been implicated in the etiology ASD. We aimed investigate autophagic markers by generating transgenerational inheritance ASD-like behaviors Cc2d1a animal model (+/-) mouse ASD was built two different groups following three generations. After behavior test, bilateral hippocampus sliced. Western Blot assay quantitative real-time polymerase chain reaction (QRT-PCR) were used for measurement LC3 Beclin-1 as key regulators autophagy. All laboratory studies conducted Erciyes University Genome Stem Cell Center (GENKOK). Significant mRNA expression levels observed between blot confirmed changes proteins hippocampus. expressions increased females decreased males compared control group. found significantly controls. This study could help explain new pathway autophagy models. Future need sex differences modeling autism-relevant genes like CC2D1A. anticipate our results starting point more comprehensive this
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