Optimizing the Delivery of 17β-estradiol: Maximizing Beneficial Cognitive Effects While Minimizing Undesired Peripheral Stimulation in a Rat Model of Surgical Menopause

Meharvan Singh, Edwin M. Meyer, William J. Millard, James W. Simpkins, Ovarian steroid deprivation results in a reversible learning impairment and compromised cholinergic function in female Sprague-Dawley rats. Brain Research. ,vol. 644, pp. 305- 312 ,(1994) , 10.1016/0006-8993(94)91694-2

S. M. Fernandez, M. C. Lewis, A. S. Pechenino, L. L. Harburger, P. T. Orr, J. E. Gresack, G. E. Schafe, K. M. Frick, Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors The Journal of Neuroscience. ,vol. 28, pp. 8660- 8667 ,(2008) , 10.1523/JNEUROSCI.1968-08.2008

Linda A. Bean, Lara Ianov, Thomas C. Foster, Estrogen Receptors, the Hippocampus, and Memory: The Neuroscientist. ,vol. 20, pp. 534- 545 ,(2014) , 10.1177/1073858413519865

Aric J Fader, Paul E.M Johnson, Gary P Dohanich, Estrogen improves working but not reference memory and prevents amnestic effects of scopolamine on a radial-arm maze Pharmacology, Biochemistry and Behavior. ,vol. 62, pp. 711- 717 ,(1999) , 10.1016/S0091-3057(98)00219-6

SANDRA J. RICHARDSON, JAMES F. NELSON, Follicular Depletion during the Menopausal Transition Annals of the New York Academy of Sciences. ,vol. 592, pp. 13- 20 ,(1990) , 10.1111/J.1749-6632.1990.TB30312.X

Robert B. Gibbs, Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocrine Reviews. ,vol. 31, pp. 224- 253 ,(2010) , 10.1210/ER.2009-0036

B. Blair Braden, Joshua S. Talboom, Ian D. Crain, Alain R. Simard, Ronald J. Lukas, Laszlo Prokai, Melissa R. Scheldrup, Bronson L. Bowman, Heather A. Bimonte-Nelson, Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats Neurobiology of Learning and Memory. ,vol. 93, pp. 444- 453 ,(2010) , 10.1016/J.NLM.2010.01.002

Jodi A. Flaws, Julie K. Doerr, I.Glenn Sipes, Patricia B. Hoyer, Destruction of preantral follicles in adult rats by 4-vinyl-1-cyclohexene diepoxide. Reproductive Toxicology. ,vol. 8, pp. 509- 514 ,(1994) , 10.1016/0890-6238(94)90033-7

Paula G Davis, Claude V Chaptal, Bruce S McEwen, Independence of the differentiation of masculine and feminine sexual behavior in rats Hormones and Behavior. ,vol. 12, pp. 12- 19 ,(1979) , 10.1016/0018-506X(79)90022-9

Lisa D. Hahner, Sohaib A. Khan, Carol F. Elias, Joel K. Elmquist, Deborah J. Clegg, Yong Xu, Thekkethil P. Nedungadi, Liangru Zhu, Nasim Sobhani, Boman G. Irani, Kathryn E. Davis, Xiaorui Zhang, Fang Zou, Lana M. Gent, Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction Cell Metabolism. ,vol. 14, pp. 453- 465 ,(2011) , 10.1016/J.CMET.2011.08.009