Gastric cancer: immunohistochemical classification of molecular subtypes and their association with clinicopathological characteristics.
作者： Eva-Maria Birkman , Naziha Mansuri , Samu Kurki , Annika Ålgars , Minnamaija Lintunen
DOI: 10.1007/S00428-017-2240-X
关键词:
摘要: Gastric cancer is traditionally divided into intestinal and diffuse histological subtypes, but recent molecular analyses have led to novel classification proposals based on genomic alterations. While the intestinal- diffuse-type tumours are distinguishable from each other at level, intestinal-type more diverse profile. The technology required for comprehensive analysis expensive not applicable routine clinical diagnostics. In this study, we used immunohistochemistry in situ hybridisation of gastric adenocarcinomas with an emphasis subtype. A tissue microarray consisting 244 was constructed, were four subgroups presence Epstein-Barr virus, TP53 aberrations microsatellite instability. separately examined. distribution EGFR HER2 gene amplifications studied tumours. virus positive common male patients (p = 0.035) most often found corpus (p = 0.011). majority proximally located (p = 0.010). All instability showed histology (p = 0.017) associated increased overall survival both univariate (p = 0.040) multivariate (p = 0.015). conclusion, study shows that can be classified biologically clinically different by using a simple method also
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