Biomass Conversion Inhibitors Furfural and 5-Hydroxymethylfurfural Induce Formation of Messenger RNP Granules and Attenuate Translation Activity in Saccharomyces cerevisiae
作者： Aya Iwaki , Takao Kawai , Yosuke Yamamoto , Shingo Izawa
DOI: 10.1128/AEM.02797-12
关键词:
摘要: Various forms of stress can cause an attenuation bulk translation activity and the accumulation nontranslating mRNAs into cytoplasmic messenger RNP (mRNP) granules termed processing bodies (P-bodies) (SGs) in eukaryotic cells. Furfural 5-hydroxymethylfurfural (HMF), derived from lignocellulosic biomass, inhibit yeast growth fermentation as stressors. Since there is no report regarding their effects on formation mRNP granules, here we investigated whether furfural HMF assembly P-bodies SGs accompanied by translational repression. We found that Saccharomyces cerevisiae. Notably, a combination induced remarkable repression initiation SG formation. These findings provide new information about physiological cells, also suggest potential usefulness warning sign or index deterioration cellular status hydrolysates.
sci-hub.se 参考文章(39)
Muriel Brengues, Daniela Teixeira, Roy Parker, Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science. ,vol. 310, pp. 486- 489 ,(2005) , 10.1126/SCIENCE.1115791
Berta Sanchez, Juan Bautista, Effects of furfural and 5-hydroxymethylfurfural on the fermentation of Saccharomyces cerevisiae and biomass production from Candida guilliermondii Enzyme and Microbial Technology. ,vol. 10, pp. 315- 318 ,(1988) , 10.1016/0141-0229(88)90135-4
Z. L. Liu, P. J. Slininger, B. S. Dien, M. A. Berhow, C. P. Kurtzman, S. W. Gorsich, Adaptive response of yeasts to furfural and 5-hydroxymethylfurfural and new chemical evidence for HMF conversion to 2,5-bis-hydroxymethylfuran Journal of Industrial Microbiology & Biotechnology. ,vol. 31, pp. 345- 352 ,(2004) , 10.1007/S10295-004-0148-3
Tobias M. Franks, Jens Lykke-Andersen, The control of mRNA decapping and P-body formation. Molecular Cell. ,vol. 32, pp. 605- 615 ,(2008) , 10.1016/J.MOLCEL.2008.11.001
J. R. Buchan, J.-H. Yoon, R. Parker, Stress-specific composition, assembly and kinetics of stress granules in Saccharomyces cerevisiae Journal of Cell Science. ,vol. 124, pp. 228- 239 ,(2011) , 10.1242/JCS.078444
M. A. M. Reijns, R. D. Alexander, M. P. Spiller, J. D. Beggs, A role for Q/N-rich aggregation-prone regions in P-body localization Journal of Cell Science. ,vol. 121, pp. 2463- 2472 ,(2008) , 10.1242/JCS.024976
Shingo IZAWA, Takeomi KITA, Kayo IKEDA, Takeo MIKI, Yoshiharu INOUE, Formation of Cytoplasmic P-Bodies in Sake Yeast during Japanese Sake Brewing and Wine Making Bioscience, Biotechnology, and Biochemistry. ,vol. 71, pp. 2800- 2807 ,(2007) , 10.1271/BBB.70417
Anneli Petersson, Joao RM Almeida, Tobias Modig, Kaisa Karhumaa, Bärbel Hahn‐Hägerdal, Marie F Gorwa‐Grauslund, Gunnar Lidén, None, A 5-hydroxymethyl furfural reducing enzyme encoded by the Saccharomyces cerevisiae ADH6 gene conveys HMF tolerance. Yeast. ,vol. 23, pp. 455- 464 ,(2006) , 10.1002/YEA.1370
Tobias Modig, João RM Almeida, Marie F Gorwa‐Grauslund, Gunnar Lidén, None, Variability of the response ofSaccharomyces cerevisiae strains to lignocellulose hydrolysate Biotechnology and Bioengineering. ,vol. 100, pp. 423- 429 ,(2008) , 10.1002/BIT.21789
Vidya Balagopal, Roy Parker, Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs Current Opinion in Cell Biology. ,vol. 21, pp. 403- 408 ,(2009) , 10.1016/J.CEB.2009.03.005