Nuclear medicine imaging of lung cancer and esophagus cancer

摘要: Background: Somatostatin receptors (SSTRs) occur in cancer tissue, and Tc-depreotide is a labelled somatostatin receptor analogue, binding to SSTRs subtype 2, 3, 5. Purpose: The general aim of the present thesis was study scintigraphy (SSTRS) with diagnosis characterization cancers lung oesophagus. Study I evaluated diagnostic value SSTRS 99 patients suspected cancer. sensitivity detect malignancy 94%, 98%. specificity calculated on two sets data. When all cases are used, 52%. If 12 pneumonias excluded, 77%. II performed 19 histologically proven non-small-cell (NSCLC), where expression SSTR 2 looked for found by immunochemical methods. quantitative evaluation using region-of-interest analysis includes tumour counts/cm, background ratio between counts. positively correlated degree tumour’s differentiation (p < 0.05). uptake cells did not correlate grade or MIB-1, p53 expression. III showed feasibility imaging oesophageal carcinoma Tcdepreotide optimal time intervals imaging. None 13 cancer-free Barrett’s oesophagus this an increased uptake. IV investigated 2A, 2B, 5 28 cancer, detected small amount adenocarcinoma absent squamous cell carcinoma. There no correlation SSTRs, tumour. Conclusion: labeled analogue has very high detecting A negative strongly suggests benign lesion, method useful decision making respect surgery. NSCLC positive presence 2. compared differentiation, p53, cannot be used as prognostic factor feasible, but suitable, either screening primary diagnosis, because method’s modest sensitivity. However, specificity. majority adenocancer have low while most do any SSTRs. © Gunnar Herlin, 2011 ISBN 978-91-7457-403-6