Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Renal Parenchymal Involvement in Infants With Febrile Urinary Tract Infection: A Preliminary Study

摘要: Background Urinary tract infection (UTI) is the most common bacterial in infants. Renal parenchymal involvement an important prognostic factor; however, early detection of UTI may be difficult during infancy. This study aimed to assess whether a recently established biomarker UTI, neutrophil gelatinase-associated lipocalin (NGAL), can serve as useful marker for cortical defects (CD) and determine appropriate diagnostic cut-off value NGAL infants with febrile UTI. Methods Infants hospitalized were divided into two groups according presence on dimercaptosuccinic acid (DMSA) scintigraphy. Among 64 enrolled infants, 43 (67%) had CD (UTI-CD) 21 (33%) no (UTI-ND). The white blood cell count, C-reactive protein, plasma (pNGAL) levels determined before antibiotic therapy compared between groups. Results pNGAL level was significantly higher UTI-CD group than UTI-ND (340 μg/L vs 214 μg/L, P=0.002). Multivariate analysis showed that only independent predictor (odds ratio 2.759, P=0.039). In ROC curve analysis, highest area under (0.745; 95% confidence interval, 0.561-0.821; P=0.014). 267 (sensitivity, 72.1%; specificity, 71.4%). Conclusions found prediction renal