Human Immunodeficiency Virus-Associated Malignancies

作者: Nathan T. Connell , Jeremy S. Abramson

DOI: 10.1128/9781555816803.CH8

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摘要: Immunodeficiency associated with the human immunodeficiency virus (HIV) has been an increased risk of malignancy since dawn AIDS epidemic. Non-Hodgkin lymphoma (NHL) and invasive cervical cancer were subsequently identified to be among HIV-infected individuals classified along Kaposi sarcoma (KS) as AIDS-defining illnesses, though numerous additional malignancies have found enriched patients living HIV/AIDS but are not considered illnesses. The association NHL HIV infection was evident early in epidemic, when unusually high number lymphomas appeared young men registries California. majority AIDS-related (ARL) will present a these factors present, placing most high-risk category. Multicentric Castleman disease (MCD) is uniformly HHV-8, pathologically benign, may occur concurrently or progress independently demonstrate rapid progression result death. Anogenital squamous cell neoplasms third common subtype HIV-associated oncogenic serotypes HPV, commonly HPV-16, -18, -19. A other malignancies, including cancers lung, liver, prostate, testes, skin, others, frequency HIV-positive patients, this trend continues introduction highly active antiretroviral therapy (HAART).

参考文章(96)
G. Pallesen, P. Skinhøj, S. J. Hamilton-Dutoit, M. B. Franzmann, C. Pedersen, J. Karkov, F. Black, AIDS-related lymphoma. Histopathology, immunophenotype, and association with Epstein-Barr virus as demonstrated by in situ nucleic acid hybridization. American Journal of Pathology. ,vol. 138, pp. 149- 163 ,(1991)
Sepkowitz Ka, Armstrong D, Murphy M, Ahkami Rn, Myskowski Pl, Regression of AIDS-related Kaposi's sarcoma following treatment with an HIV-1 protease inhibitor. AIDS. ,vol. 11, pp. 261- 262 ,(1997)
A Mocroft, R Halai, B Gazzard, J Morcinek, A N Phillips, M Youle, Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group. AIDS. ,vol. 10, pp. 1101- 1105 ,(1996)
Antonino Carbone, Annunziata Gloghini, Gianluca Gaidano, Anna Maria Cilia, Paola Bassi, Pietro Polito, Emanuela Vaccher, Giuseppe Saglio, Umberto Tirelli, AIDS-related Burkitt's lymphoma. Morphologic and immunophenotypic study of biopsy specimens. American Journal of Clinical Pathology. ,vol. 103, pp. 561- 567 ,(1995) , 10.1093/AJCP/103.5.561
E Vittinghoff, S Scheer, Scott Holmberg, P O'Malley, G Colfax, SP Buchbinder, Combination antiretroviral therapy and incidence of AIDS-related malignancies. Journal of Acquired Immune Deficiency Syndromes. ,vol. 21, ,(1999)
S Franceschi, , L Dal Maso, S Arniani, P Crosignani, M Vercelli, L Simonato, F Falcini, R Zanetti, A Barchielli, D Serraino, G Rezza, Risk of cancer other than Kaposi's sarcoma and non-Hodgkin's lymphoma in persons with AIDS in Italy British Journal of Cancer. ,vol. 78, pp. 966- 970 ,(1998) , 10.1038/BJC.1998.610
More on HIV-Associated Kaposi’s Sarcoma The New England Journal of Medicine. ,vol. 358, pp. 535- 536 ,(2008) , 10.1056/NEJMC072994
H Knecht, M Raphael, C McQuain, S Rothenberger, G Pihan, S Camilleri-Broet, E Bachmann, GR Kershaw, S Ryan, EL Kittler, PJ Quesenberry, D Schlaifer, BA Woda, P Brousset, Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations Blood. ,vol. 87, pp. 876- 881 ,(1996) , 10.1182/BLOOD.V87.3.876.BLOODJOURNAL873876
E Cesarman, R G Nador, F Bai, R A Bohenzky, J J Russo, P S Moore, Y Chang, D M Knowles, Kaposi's sarcoma-associated herpesvirus contains G protein-coupled receptor and cyclin D homologs which are expressed in Kaposi's sarcoma and malignant lymphoma. Journal of Virology. ,vol. 70, pp. 8218- 8223 ,(1996) , 10.1128/JVI.70.11.8218-8223.1996