Multimodal imaging probes based on Gd-DOTA conjugated quantum dot nanomicelles

摘要: Recently, multimodal nanoparticles integrating dual- or tri-imaging modalities into a single hybrid nanosystem have attracted plenty of attention in biomedical research. Here, we report the fabrication two types micelle-encapsulated nanoparticles, which were systematically characterized and thoroughly evaluated terms their imaging potential biocompatibility. Optical magnetic resonance (MR) probes integrated by conjugating DOTA-gadolinium (Gd) derivative to quantum dot based nanomicelles. Two amphiphilic block copolymer micelles, amine-terminated mPEG-phospholipid amine-modified Pluronic F127, chosen as capping agents because excellent biocompatibility ability prevent opsonization prolong circulation time vivo. Owing different hydrophobic–hydrophilic structure, micellar aggregates exhibited sizes protection core QDs. This work revealed differences between these nanomicelles stability over wide range pH, along with cytotoxicity capacity for chelating gadolinium, thus providing useful guideline tailor-making specific applications.