Cytoreductive surgery of glioblastoma as the key to successful adjuvant therapies: new arguments in an old discussion.
作者： Walter Stummer , Martin J. van den Bent , Manfred Westphal
DOI: 10.1007/S00701-011-1001-X
关键词:
摘要: This article discusses data from 3 randomized phase trials, supporting a role for surgery in glioblastoma. Data were reviewed by extent of resection during primary the ALA-Glioma Study (fluorescence-guided versus conventional resection), BCNU wafer study (BCNU placebo), and EORTC 26981–22981 (radiotherapy chemoradiotherapy with temozolomide). For glioblastoma patients ALA study, median survival was 16.7 11.8 months complete partial resection, respectively (P < 0.0001). Survival effects maintained after correction differences age tumor location. who received ≥90% increased placebo (14.5 12.4 months, respectively; P = 0.02), but no increase found <90% (11.7 10.6 months, P = 0.98). In absolute gain radiotherapy greatest resections (+4.1 months; P = 0.0001), compared (+1.8 months; or biopsies (+1.5 months; P = 0.088), suggesting enhanced adjuvant treatment. Complete appears to improve may efficacy adjunct/adjuvant therapies. If safely achievable, should be surgical goal
springer.com
sci-hub.se 参考文章(47)
Ivar Mendez, Philip Jacobs, Andrea MacDougall, Margarita Schultz, Treatment costs for glioblastoma multiforme in Nova Scotia. Canadian Journal of Neurological Sciences. ,vol. 28, pp. 61- 65 ,(2001) , 10.1017/S0317167100052574
Michael J. Winger, David R. Macdonald, J. Gregory Cairncross, Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma. Journal of Neurosurgery. ,vol. 71, pp. 487- 493 ,(1989) , 10.3171/JNS.1989.71.4.0487
Kenneth R. Hess, Extent of resection as a prognostic variable in the treatment of gliomas. Journal of Neuro-oncology. ,vol. 42, pp. 227- 231 ,(1999) , 10.1023/A:1006118018770
V. Vuorinen, S. Hinkka, M. Färkkilä, J. Jääskeläinen, Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochirurgica. ,vol. 145, pp. 5- 10 ,(2003) , 10.1007/S00701-002-1030-6
Charles B. Scott, James S. Nelson, Nancy C. Farnan, Walter J. Curran, Kevin J. Murray, A. Jennifer Fischbach, Laurie E. Gaspar, Diana F. Nelson, Central pathology review in clinical trials for patients with malignant glioma. A report of radiation therapy oncology group 83‐02 Cancer. ,vol. 76, pp. 307- 313 ,(1995) , 10.1002/1097-0142(19950715)76:2<307::AID-CNCR2820760222>3.0.CO;2-L
Jonathan P.S Knisely, Sara Rockwell, Importance of hypoxia in the biology and treatment of brain tumors Neuroimaging Clinics of North America. ,vol. 12, pp. 525- 536 ,(2002) , 10.1016/S1052-5149(02)00032-1
M. Westphal, Z. Ram, V. Riddle, D. Hilt, E. Bortey, , Gliadel wafer in initial surgery for malignant glioma: long-term follow-up of a multicenter controlled trial. Acta Neurochirurgica. ,vol. 148, pp. 269- 275 ,(2006) , 10.1007/S00701-005-0707-Z
Marianne Koritzinsky, Renaud Seigneuric, Michaël G. Magagnin, Twan van den Beucken, Philippe Lambin, Bradly G. Wouters, The hypoxic proteome is influenced by gene-specific changes in mRNA translation Radiotherapy and Oncology. ,vol. 76, pp. 177- 186 ,(2005) , 10.1016/J.RADONC.2005.06.036
Edward R. Laws, Ian F. Parney, Wei Huang, Fred Anderson, Angel M. Morris, Anthony Asher, Kevin O. Lillehei, Mark Bernstein, Henry Brem, Andrew Sloan, Mitchel S. Berger, Susan Chang, _ _, Survival following surgery and prognostic factors for recently diagnosed malignant glioma: data from the Glioma Outcomes Project. Journal of Neurosurgery. ,vol. 99, pp. 467- 473 ,(2003) , 10.3171/JNS.2003.99.3.0467
Bertrand C. Devaux, Judith R. O'Fallon, Patrick J. Kelly, Resection, biopsy, and survival in malignant glial neoplasms. A retrospective study of clinical parameters, therapy, and outcome. Journal of Neurosurgery. ,vol. 78, pp. 767- 775 ,(1993) , 10.3171/JNS.1993.78.5.0767