Prenatal Stress or High Fat Diet increases Susceptibility to Diet-Induced Obesity in Rat Offspring

摘要: OBJECTIVE Perturbations to the prenatal environment have been associated with development of adult chronic disease, findings that gave rise “Barker Hypothesis” or “developmental origins disease” concept. In this study, we used an animal model determine metabolic consequences maternal stress and high-fat feeding on developing offspring. RESEARCH DESIGN AND METHODS Pregnant female Sprague-Dawley rats were maintained standard chow 60% diet throughout gestation lactation. Half each group exposed a novel variable paradigm during 3rd week gestation, whereas control dams left undisturbed. Body weight, body composition, glucose tolerance, endocrine parameters measured in offspring through early adulthood. RESULTS Male pups from experienced and/or weighed more beginning postnatal day 7 compared chow–control pups. Access at weaning increased weight effect adulthood was attributable greater adiposity. Pups weaned onto showed no significant difference clearance insulin secretion. However, had impaired tolerance if their diet, stress, both. CONCLUSIONS Our data demonstrate intrauterine affects manner increases susceptibility diet-induced obesity leads secondary adverse consequences.