Immunogenicity and Safety of Two Doses of a Paediatric Hepatitis A Vaccine in Thai Children: Comparison of Three Vaccination Schedules

摘要: As fewer children in Thailand are exposed to hepatitis A virus (HAV) and so do not have seroprotective anti-HAV antibodies, they becoming an important source of HAV transmission. flexible vaccination schedule would facilitate incorporation the vaccine into existing immunization programmes, we compared immunogenicity safety three schedules. An open, randomized, clinical trial was carried out which healthy were given a primary dose inactivated vaccine, Avaxim 80 paediatric, with booster 6, 12 or 18 months later. Anti-HAV geometric mean concentrations (GMC), seroconversion rates, GMC ratios (GMCR) schedules reactogenicity evaluated. Seroconversion rates above 98 per cent (per group) up booster. The equivalent terms GMCRs, each eliciting large effect. Local reactions reported for than 9 group after one less frequently dose. Injection site pain, gastrointestinal tract disorders fever most commonly adverse events. No vaccine-related serious events reported. It concluded that is safe immunogenic when as two-dose seronegative aged 5-10 years, second at either first.