Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans.
作者： Nancy J. Cox , Mike Frigge , Dan L. Nicolae , Patrick Concannon , Craig L. Hanis
DOI: 10.1038/6002
关键词:
摘要: Complex disorders such as diabetes, cardiovascular disease, asthma, hypertension and psychiatric illnesses account for a large disproportionate share of health care costs, but remain poorly characterized with respect to aetiology. The transmission is complex, reflecting the actions interactions multiple genetic environmental factors. Genetic analyses that allow simultaneous consideration susceptibility from regions may improve ability map genes complex disorders, are currently computationally intensive narrowly focused. We describe here an approach assessing evidence statistical between unlinked allows multipoint allele-sharing analysis take linkage at one region into in over rest genome. Using this method, we show interaction on chromosomes 2 (NIDDM1) 15 (near CYP19) makes contribution type diabetes Mexican Americans Starr County, Texas.
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