Chronic polychlorinated biphenyls exposure on three generations of oldfield mice (Peromyscus polionotus): effects on reproduction, growth, and body residues.

摘要: Effects of chronic dietary exposure to low levels PCBs (polychlorinated biphenyls) on reproduction, growth and whole body burdens were investigated in three generations Peromyscus polionotus. Mated pairs maintained a diet containing 5 mg/kg (Aroclor 1254®) for 12 months, beginning as young adults; matched controls received similar without PCBs. Offspring the parental regime paired at maturity with non-siblings same group. In first second generation offspring, birth weaning weights significantly lower PCB-exposed animals; generation, there also fewer mice born/month, longer intervals prior litter, decreased survival (25 days) among exposed mice. Whole residue increased each exposure. This study clearly shows that dosage depressed fertility, Peromyscus, these effects amplified through multigenerational