Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans.

摘要: The beneficial health effects attributed to the consumption of fruit and vegetables are related, at least in part, their antioxidant activity. Of special interest is inverse relationship between intake dietary nutrients rich polyphenols cardiovascular diseases. This effect polyphenols' ability inhibit low-density lipoprotein (LDL) oxidation, macrophage foam cell formation atherosclerosis. Pomegranate can protect LDL against cell-mediated oxidation via two pathways, including either direct interaction with and/or an indirect through accumulation arterial macrophages. were shown reduce capacity macrophages oxidatively modify LDL, due its by scavenging reactive oxygen species nitrogen also macrophages; hence, inhibition lipid peroxidation peroxide-rich Furthermore, pomegranate increase serum paraoxonase activity, resulting hydrolysis peroxides oxidized lipoproteins atherosclerotic lesions. These antioxidative antiatherogenic demonstrated vitro, as well vivo humans apolipoprotein E deficient mice. Dietary supplementation polyphenol-rich juice mice significantly inhibited development lesions this may be protection oxidation.