Randomized Clinical Trials in Localized Anal Cancer

摘要: Management of anal carcinoma began as abdominoperineal resection and has evolved to combined chemotherapy radiation. Early randomized trials demonstrated superior clinical outcomes modality therapy over radiotherapy alone. Subsequent investigated alterations in the standard backbone concurrent with 5-fluorouracil mitomycin C intent maintain while reducing treatment-related morbidity. The addition intensity-modulated radiation planning delivery subsequently reduced acute toxicity detrimental treatment breaks. Ongoing future are aimed at favorable patient populations decrease morbidity intensifying patients negative prognostic factors.