Determinants of coronary reserve in rats subjected to coronary artery ligation or aortic banding.
作者： E KALKMAN , Y BILGIN , P HAREN , R SUYLEN , P SAXENA
DOI: 10.1016/S0008-6363(96)00166-6
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摘要: Objective: We investigated whether decreased coronary reserve in hearts after artery ligation or from rats aortic banding can be related to remodeling of resistance arteries. Methods: Maximal flow (absolute flow) and cardiac perfusion (flow corrected for heart weight) were determined isolated, perfused rat adenosine nitroprusside, at 3 8 weeks 4–5 banding. Perivascular collagen medial thickness arteries by morphometry. Results: infarcted had been restored sham values weeks. Growth muscle mass exceeded the increase maximal flow, leading a A slight, transient perivascular collagen, but no hypertrophy, was found infarction. After banding, fibrosis hypertrophy led both hypertrophied left non-hypertrophied right ventricle. Consequently, ventricle most severely reduced. Conclusions: Reduced is vascular remodeling. In contrast, during infarction-induced remodeling, reduction not mainly disproportional relative growth.
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