摘要: Binding of catecholamines to the beta-adrenergic receptor results in activation adenylate cyclase and intracellular formation adenosine 3',5'-monophosphate (cAMP). In past 20 years events that lead from hormone binding at cell surface site synthesis cAMP inner layer membrane have been intensively studied. Signal transduction this system involves sequential interaction with guanine nucleotide-binding protein (Gs) catalyst (C). The mechanism signal through Gs C, as well role inhibitory G Gi, is discussed.
sciencemag.org
harvard.edu参考文章(108)
Y.F. Su, T.K. Harden, J.P. Perkins, Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process. Journal of Biological Chemistry. ,vol. 255, pp. 7410- 7419 ,(1980) , 10.1016/S0021-9258(20)79718-8
T N Lavin, P Nambi, S L Heald, P W Jeffs, R J Lefkowitz, M G Caron, 125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors. Journal of Biological Chemistry. ,vol. 257, pp. 12332- 12340 ,(1982) , 10.1016/S0021-9258(18)33718-9
M L Toews, G L Waldo, T K Harden, J P Perkins, Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization. Journal of Biological Chemistry. ,vol. 259, pp. 11844- 11850 ,(1984) , 10.1016/S0021-9258(20)71288-3
I B Abrass, P J Scarpace, L A Baresi, D A Sanford, Desensitization and resensitization of beta-adrenergic receptors in a smooth muscle cell line. Molecular Pharmacology. ,vol. 28, pp. 495- 501 ,(1985)
E M Ross, A G Gilman, Resolution of some components of adenylate cyclase necessary for catalytic activity. Journal of Biological Chemistry. ,vol. 252, pp. 6966- 6969 ,(1977) , 10.1016/S0021-9258(19)66920-6
W B Anderson, C J Jaworski, Isoproterenol-induced desensitization of adenylate cyclase responsiveness in a cell-free system. Journal of Biological Chemistry. ,vol. 254, pp. 4596- 4601 ,(1979) , 10.1016/S0021-9258(17)30052-2
E.M. Ross, A.C. Howlett, K.M. Ferguson, A.G. Gilman, Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. Journal of Biological Chemistry. ,vol. 253, pp. 6401- 6412 ,(1978) , 10.1016/S0021-9258(19)46947-0
Martin Rodbell, H. Michiel J. Krans, Stephen L. Pohl, Lutz Birnbaumer, The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver IV. EFFECTS OF GUANYL NUCLEOTIDES ON BINDING OF 125I-GLUCAGON Journal of Biological Chemistry. ,vol. 246, pp. 1872- 1876 ,(1971) , 10.1016/S0021-9258(18)62389-0
G L Waldo, J K Northup, J P Perkins, T K Harden, Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization. Journal of Biological Chemistry. ,vol. 258, pp. 13900- 13908 ,(1983) , 10.1016/S0021-9258(17)44003-8
B Strulovici, J M Stadel, R J Lefkowitz, Functional integrity of desensitized beta-adrenergic receptors. Journal of Biological Chemistry. ,vol. 258, pp. 6410- 6414 ,(1983) , 10.1016/S0021-9258(18)32425-6