Progression of kidney disease in chronic renal transplant rejection

摘要: The rate of progression renal insufficiency was quantitated from reciprocal serum creatinine versus time plots in patients with clinical and histologic evidence chronic transplant rejection. were evaluated by the breakpoint test. This method identifies breakpoints a linear plot compares statistical significance fit provided two intersecting lines that single straight line. test when applied to 22 significant correlation between detected change slope 20 cases (90.9%) indicating presence breakpoint. average diastolic, systolic, mean arterial pressures before significantly correlated value at (r = 0.45, P less than 0.05; r 0.58, 0.01; 0.56, 0.05, respectively) demonstrating more severe hypertension those dysfunction. after diastolic blood pressure values 0.48, 0.05) higher being found faster rates decline function. Both occurred, disease, as estimated plot, greater 90 mmHg. In conclusion, vast majority proven rejection progress linearly although frequent. Higher levels correlate insufficiency, associates