Cytokine Tuning of Intestinal Epithelial Function.

摘要: The intestine serves as both our largest single barrier to the external environment and host of more immune cells than any other location in bodies. Separating these potential combatants is a layer dynamic epithelium composed heterogeneous epithelial subtypes, each uniquely adapted carry out subset intestine’s diverse functions. In addition its obvious role digestion, intestinal responsible for wide array critical tasks, including maintaining integrity, preventing invasion by microbial commensals pathogens, modulating system. Communication between resident crucial homeostasis coordinating appropriate responses disease can occur through cell-to-cell contact or release recognition soluble mediators. objective this review highlight recent literature illuminating how cytokines chemokines, those made acting on epithelium, orchestrate many functions interactions with health disease. Areas focus include cytokine control proliferation, cell death, permeability. Additionally, modulation epithelial-derived chemokines factors such stromal cells, pathogen commensal exposure, diet will be discussed.