Minimally Invasive Biomaterials for Central Nervous System Therapies

作者: Britta Rauck

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摘要: The inability of the adult central nervous system (CNS) to regenerate combined with progressive nature many CNS pathologies poses a significant challenge in developing effective treatments. Biomaterials-based systems designed deliver drugs and/or cells hold immense potential for moderating disease progression and promoting repair. Ideally, such should (1) allow minimally invasive administration, (2) provide localized controlled delivery, (3) protect activity their cargo maximal therapeutic effect. Additionally, ability incorporate multiple treatment modalities is desirable as disorders are multi-faceted complex nature. Designing delivery that these features while simultaneously improving outcomes, however, challenge. This dissertation covers formulation application polymer-based repair, specific focus given spinal cord visual systems. We first demonstrated biocompatibility feasibility reverse thermal gel, poly(ethylene glycol)–poly(serinol hexamethylene urethane) (ESHU) intraocular drug delivery. injectable capable sustaining bevacizumab release vivo, ultimately may be used reduce injection frequency patients ocular diseases age-related macular degeneration. To emphasize versatility ESHU, it was bone marrow stromal (BMSCs) traumatic injury rats. ESHU improved BMSC survival 3.5-fold one week post-injury compared BMSCs injected PBS, which accompanied by increased tissue sparing functional recovery. Finally, we coacervate-based growth factor injury. Ultimately, hope coacervate combination augment cell therapy drive development innovative solutions treat injuries where there no cures.

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