Endothelial nitric oxide synthase gene polymorphisms in Behçet's disease.
作者： Luigi Boiardi , Marcello Govoni , Carlo Salvarani , Ignazio Olivieri , Renato Malatesta
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摘要: OBJECTIVE: To analyze potential associations of Glu-Asp298 polymorphism in exon 7 and 4 a/b intron the endothelial nitric oxide synthase (eNOS) gene with susceptibility for Behcet9s disease (BD). METHODS: Seventy-three consecutive Italian patients who satisfied International Study Group criteria BD 135 healthy blood donor controls from same geographic area were genotyped by polymerase chain reaction allele-specific oligonucleotide techniques eNOS polymorphisms 4. RESULTS: The distribution genotype differed significantly between (p(corr) = 0.00009). Allele Asp298 was more frequent than 0.0006, OR 2.1, 95% CI 1.5-3.3). similar controls. CONCLUSION: Our findings show that is associated susceptibility.
elsevier.com参考文章(31)
R M Palmer, S Moncada, E A Higgs, NITRIC OXIDE: PHYSIOLOGY, PATHOPHYSIOLOGY, AND PHARMACOLOGY Pharmacological Reviews. ,vol. 43, pp. 109- 142 ,(1991)
H Direskeneli, G Keser, D D'cruz, MA Khamashta, T Akoğlu, H Yazici, S Yurdakul, Vedat Hamuryudan, Ş Özgun, AJ Goral, GRV Hughes, None, Anti-endothelial cell antibodies, endothelial proliferation and von Willebrand factor antigen in Behçet's disease Clinical Rheumatology. ,vol. 14, pp. 55- 61 ,(1995) , 10.1007/BF02208085
Robinson Joannides, Walter E. Haefeli, Lilly Linder, Vincent Richard, El Hassan Bakkali, Christian Thuillez, Thomas F. Lüscher, Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo Circulation. ,vol. 91, pp. 1314- 1319 ,(1995) , 10.1161/01.CIR.91.5.1314
K. Özoran, N. Düzgun, A. Gürler, H. Tutkak, G. Tokgöz, Plasma von Willebrand factor, tissue plasminogen activator, plasminogen activator inhibitor, and antithrombin III levels in Behçet's disease. Scandinavian Journal of Rheumatology. ,vol. 24, pp. 376- 382 ,(1995) , 10.3109/03009749509095184
A Örem, BİRGÜL Vanizor, G Cimşit, E Kıran, O Değer, MELTEM Malkoç, None, Decreased Nitric Oxide Production in Patients with Behçet’s Disease Dermatology. ,vol. 198, pp. 33- 36 ,(1999) , 10.1159/000018061
Toshihiko Tsukada, Keitaro Yokoyama, Tomoko Arai, Fumi Takemoto, Sigeko Hara, Akira Yamada, Yoshindo Kawaguchi, Tatsuo Hosoya, Jun Igari, Evidence of Association of the ecNOS Gene Polymorphism with Plasma NO Metabolite Levels in Humans Biochemical and Biophysical Research Communications. ,vol. 245, pp. 190- 193 ,(1998) , 10.1006/BBRC.1998.8267
M.W Radomski, R.M.J Palmer, S Moncada, Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. The Lancet. ,vol. 330, pp. 1057- 1058 ,(1987) , 10.1016/S0140-6736(87)91481-4
John C Chambers, Dorian O Haskard, Jaspal S Kooner, Vascular endothelial function and oxidative stress mechanisms in patients with Behçet’s syndrome Journal of the American College of Cardiology. ,vol. 37, pp. 517- 520 ,(2001) , 10.1016/S0735-1097(00)01137-2
R. M. J. Palmer, A. G. Ferrige, S. Moncada, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor Nature. ,vol. 327, pp. 524- 526 ,(1987) , 10.1038/327524A0
F.G.R Fowkes, A.J Lee, C.M Hau, A Cooke, J.M Connor, G.D.O Lowe, Methylene tetrahydrofolate reductase (MTHFR) and nitric oxide synthase (ecNOS) genes and risks of peripheral arterial disease and coronary heart disease: Edinburgh artery study Atherosclerosis. ,vol. 150, pp. 179- 185 ,(2000) , 10.1016/S0021-9150(99)00366-4