Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways.

作者: Boris Rodenak-Kladniew , Agustina Castro , Peter Stärkel , Christine De Saeger , Margarita García de Bravo

DOI: 10.1016/J.LFS.2018.03.006

关键词:

摘要: … Akt/mTOR pathway in HepG2 cell cycle arrest induced by linalool and support the pro-survival role of Akt … at linalool 1.0 and 1.5 mM despite Akt inhibition may be due to other kinases …

参考文章(46)
P.L. Crowell, R.R. Chang, Z.B. Ren, C.E. Elson, M.N. Gould, Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites. Journal of Biological Chemistry. ,vol. 266, pp. 17679- 17685 ,(1991) , 10.1016/S0021-9258(19)47425-5
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Huanbiao Mo, Charles E. Elson, Studies of the isoprenoid-mediated inhibition of mevalonate synthesis applied to cancer chemotherapy and chemoprevention. Experimental Biology and Medicine. ,vol. 229, pp. 567- 585 ,(2004) , 10.1177/153537020422900701
Ana Clara Aprotosoaie, Monica Hăncianu, Irina-Iuliana Costache, Anca Miron, Linalool: a review on a key odorant molecule with valuable biological properties Flavour and Fragrance Journal. ,vol. 29, pp. 193- 219 ,(2014) , 10.1002/FFJ.3197
Qiao Zhang, Can Cui, Cong-Qin Chen, Xiao-Long Hu, Ya-Hui Liu, Yan-Hua Fan, Wei-Hong Meng, Qing-Chun Zhao, Anti-proliferative and pro-apoptotic activities of Alpinia oxyphylla on HepG2 cells through ROS-mediated signaling pathway. Journal of Ethnopharmacology. ,vol. 169, pp. 99- 108 ,(2015) , 10.1016/J.JEP.2015.03.073
S. Lim, P. Kaldis, Cdks, cyclins and CKIs: roles beyond cell cycle regulation Development. ,vol. 140, pp. 3079- 3093 ,(2013) , 10.1242/DEV.091744
Marianela Galle, Rosana Crespo, Boris Rodenak Kladniew, Sandra Montero Villegas, Mónica Polo, Margarita G. de Bravo, Suppression by Geraniol of the Growth of A549 Human Lung Adenocarcinoma Cells and Inhibition of the Mevalonate Pathway in Culture and In Vivo: Potential Use in Cancer Chemotherapy Nutrition and Cancer. ,vol. 66, pp. 888- 895 ,(2014) , 10.1080/01635581.2014.916320
Michelle C. Mendoza, E. Emrah Er, John Blenis, The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation Trends in Biochemical Sciences. ,vol. 36, pp. 320- 328 ,(2011) , 10.1016/J.TIBS.2011.03.006
N Charette, C De Saeger, Y Horsmans, I Leclercq, P Stärkel, Salirasib sensitizes hepatocarcinoma cells to TRAIL-induced apoptosis through DR5 and survivin-dependent mechanisms. Cell Death and Disease. ,vol. 4, pp. 0- ,(2013) , 10.1038/CDDIS.2012.200