PTP1B and TCPTP--nonredundant phosphatases in insulin signaling and glucose homeostasis
作者： Tony Tiganis
DOI: 10.1111/J.1742-4658.2012.08563.X
关键词:
摘要: Insulin resistance is a key pathological feature of type 2 diabetes and characterized by defects in signaling the insulin receptor (IR) protein tyrosine kinase. The inhibition phosphatases (PTPs) that antagonize IR may provide means for enhancing response alleviating resistance. prototypic phosphotyrosine-specific phosphatase PTP1B dephosphorylates attenuates muscle liver. Mice are deficient exhibit improved glucose homeostasis diet genetic models diabetes. TCPTP shares 72% catalytic domain sequence identity with has also been implicated regulation. Despite their high degree similarity, act together vitro vivo to regulate homeostasis. This review highlights capacity specifically nonredundantly cellular signaling, describes roles regulation homeostasis, discusses potential as drug targets enhancement phosphorylation sensitivity
sci-hub.se 参考文章(135)
N K Tonks, C D Diltz, E H Fischer, Purification of the major protein-tyrosine-phosphatases of human placenta. Journal of Biological Chemistry. ,vol. 263, pp. 6722- 6730 ,(1988) , 10.1016/S0021-9258(18)68702-2
N K Tonks, C D Diltz, E H Fischer, Characterization of the major protein-tyrosine-phosphatases of human placenta. Journal of Biological Chemistry. ,vol. 263, pp. 6731- 6737 ,(1988) , 10.1016/S0021-9258(18)68703-4
Barry J. Goldstein, Faiyaz Ahmad, Wendi Ding, Pei-Ming Li, Wei-Ren Zhang, Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases Insulin Action. ,vol. 182, pp. 91- 99 ,(1998) , 10.1007/978-1-4615-5647-3_10
Michael P. Myers, Jannik N. Andersen, Alan Cheng, Michel L. Tremblay, Curt M. Horvath, Jean-Patrick Parisien, Annette Salmeen, David Barford, Nicholas K. Tonks, TYK2 and JAK2 Are Substrates of Protein-tyrosine Phosphatase 1B Journal of Biological Chemistry. ,vol. 276, pp. 47771- 47774 ,(2001) , 10.1074/JBC.C100583200
Morris F. White, The IRS-signalling system: A network of docking proteins that mediate insulin action Insulin Action. ,vol. 182, pp. 3- 11 ,(1998) , 10.1007/978-1-4615-5647-3_1
Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery, Deborah J. Burks, Jian-Ming Ren, Stephen Previs, Yitao Zhang, Dolores Bernal, Sebastian Pons, Gerald I. Shulman, Susan Bonner-Weir, Morris F. White, Disruption of IRS-2 causes type 2 diabetes in mice Nature. ,vol. 391, pp. 900- 904 ,(1998) , 10.1038/36116
Paul G. Drake, Barry I. Posner, Insulin receptor-associated protein tyrosine phosphatase(s): Role in insulin action Molecular and Cellular Biochemistry. ,vol. 182, pp. 79- 89 ,(1998) , 10.1023/A:1006808100755
Tony Tiganis, Bruce E. Kemp, Nicholas K. Tonks, The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling. Journal of Biological Chemistry. ,vol. 274, pp. 27768- 27775 ,(1999) , 10.1074/JBC.274.39.27768
Manuela Klingler-Hoffmann, Michelle T. Fodero-Tavoletti, Kazuhiko Mishima, Yoshitaka Narita, Webster K. Cavenee, Frank B. Furnari, H.-J. Su Huang, Tony Tiganis, The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor. Journal of Biological Chemistry. ,vol. 276, pp. 46313- 46318 ,(2001) , 10.1074/JBC.M106571200
Cheng Sun, Fang Zhang, Xinjian Ge, Tingting Yan, Xingmiao Chen, Xianglin Shi, Qiwei Zhai, SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metabolism. ,vol. 6, pp. 307- 319 ,(2007) , 10.1016/J.CMET.2007.08.014