[11] Sialic acid analogs and application for preparation of neoglycoconjugates
作者： Reinhard Brossmer , Hans Jürgen Gross
DOI: 10.1016/S0076-6879(94)47013-8
关键词:
摘要: Publisher Summary Neoglycoproteins carrying terminal 9-amino-NeuAc in α2, 6-linkage has been derived from several human plasma glycoproteins by enzymatic remodeling. Termination of glycoconjugate glycans the sialidase-resistant sialic acid analog deserves special interest as it blocks catabolism bacterial, viral, or mammalian sialidases. Among purified sialyltransferase studied, only lactosaminespecific α-2, 6-sialyltransferases effectively transfer zwitterionic analog. The chapter reveals that, within specificity limitations sialyltransferase, synthesis is a suitable procedure for introducing analogs into defined sequences soluble membrane-bound glycolipids according to respective acceptor specificity. In particular, specifically modified at C-4, C-5, C-9 positions may thus be tailored influence distinct recognition event.
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