Synovial sarcoma of the kidney with rhabdoid features: report of three cases.

摘要: We report 3 cases of synovial sarcoma with rhabdoid features, initially diagnosed as adult tumors. Two women (case nos. 1 and 2, 35 years 27 age, respectively) one man no. 3, 26 age) presented to their physicians right flank pain. On physical examination, a poorly defined, firm, palpable mass was found in the upper quadrant abdomen all cases. Sonography computed tomography revealed solid, cystic masses kidneys that ranged size from 8.5 20.0 cm. Right radical nephrectomies were performed patients. One patient died disease, other two patients alive disease-free after chemotherapy radiotherapy. Microscopic examination tumors composed mostly cells eccentrically located nuclei, prominent nucleoli, eosinophilic cytoplasm. also areas fasciculated spindle cells, sharply separated or irregularly admixed cells. There tumor necrosis, but no epithelial seen. Hemangiopericytic vasculature at least focally observed The positive for CD99 bcl-2 CD56 negative CD34 smooth muscle actin case cytokeratin. To verify possibility reverse transcriptase polymerase chain reaction using RNA extracted frozen tissue formalin-fixed, paraffin-embedded 2 performed. SYT-SSX2 transcripts detected These indicate kidney should be considered differential diagnosis mesenchymal features. A subset may variant sarcoma, molecular studies detect SYT-SSX fusion are recommended an accurate diagnosis.