Matrix rigidity regulates the transition of tumor cells to a bone-destructive phenotype through integrin β3 and TGF-β receptor type II.

作者: Jonathan M. Page , Alyssa R. Merkel , Nazanin S. Ruppender , Ruijing Guo , Ushashi C. Dadwal

DOI: 10.1016/J.BIOMATERIALS.2015.06.026

关键词:

摘要: … rigid than the primary site, stimulates their transition from the pre-osteolytic to the osteolytic phase. We further postulated that the transition to the osteolytic phenotype on substrates with …

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