68Ga-DOTATATE PET/CT, 99mTc-HYNIC-Octreotide SPECT/CT, and Whole-Body MR Imaging in Detection of Neuroendocrine Tumors: A Prospective Trial

摘要: There are different metabolic imaging methods, various tracers, and emerging anatomic modalities to stage neuroendocrine tumor (NET). We aimed compare NET lesion detectability among 99mTc-hydrazinonicotinamide (HYNIC)-octreotide (somatostatin receptor scintigraphy [SSRS]) SPECT/CT, 68Ga-DOTATATE PET/CT, whole-body diffusion-weighted MR (WB DWI). Methods: Nineteen consecutive patients (34–77 y old; mean, 54.3 ± 10.4 10 men 9 women) underwent SSRS WB DWI. Images were acquired with a maximum interval of 3 mo between them analyzed masking by separate teams. Planar SPECT/CT performed from thorax pelvis using double-head 16-slice scanner 4 h after injection 111–185 MBq 99mTc-HYNIC-octreotide. PET/CT was head feet 45 min 185 tracer. DWI in the coronal plane 1.5-T body coil. The standard method reference for evaluation image performance undertaken: consensus investigators at end study, clinical follow-up, biopsy suggestive lesions. Results: McNemar testing applied evaluate lesions comparison DWI: significant difference noted pancreas (P = 0.0455 P 0.0455, respectively), gastrointestinal tract 0.0455), bones 0.0082 0.0082). Two unknown primary identified solely PET/CT. demonstrated, respectively, sensitivities 0.96, 0.60, 0.72; specificities 0.97, 0.99, 1.00; positive predictive values 0.94, negative 0.98, 0.83, 0.88; accuracies 0.86, 0.91. Conclusion:68Ga seems be more sensitive detection well-differentiated lesions, especially bone can staged is an efficient new high accuracy without ionizing radiation exposure. should used only when not available.