Sex, gut microbiome, and cardiovascular disease risk

摘要: Key differences exist between men and women in the determinants manifestations of cardiovascular cardiometabolic diseases. Recently, gut microbiome-host relations have been implicated disease associated metabolic conditions; therefore, microbiota may be key mediators or modulators driving observed sexual dimorphism onset progression. While current evidence regarding pure physiological sex microbiome composition is modest, robust research suggests that microbiome-dependent metabolites interact with important biological pathways under hormone control, including toll-like receptor flavin monooxygenase signaling. Here, we review interactions four primary disease, impaired glucose regulation, dyslipidemia, hypertension, obesity. Through this process, propose downstream at interface disease.