Atomic basis of CRM1-cargo recognition, release and inhibition.

作者: Ho Yee Joyce Fung , Yuh Min Chook

DOI: 10.1016/J.SEMCANCER.2014.03.002

关键词:

摘要: … complex, (C) with the SNUPN NES bound, (D) the NES peptide removed to view the … The entire SNUPN NES adopts a helix-loop conformation. Met1 of the SNUPN NES was thus …

参考文章(136)
Dabauvalle Mc, Scheer U, Wilken N, Senécal Jl, Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex. European Journal of Cell Biology. ,vol. 68, pp. 211- 219 ,(1995)
F.R. Bischoff, H. Krebber, E. Smirnova, W. Dong, H. Ponstingl, Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1 The EMBO Journal. ,vol. 14, pp. 705- 715 ,(1995) , 10.1002/J.1460-2075.1995.TB07049.X
Makoto Fukuda, Shiro Asano, Takahiro Nakamura, Makoto Adachi, Minoru Yoshida, Mitsuhiro Yanagida, Eisuke Nishida, None, CRM1 is responsible for intracellular transport mediated by the nuclear export signal Nature. ,vol. 390, pp. 308- 311 ,(1997) , 10.1038/36894
W. Wen, A.T. Harootunian, S.R. Adams, J. Feramisco, R.Y. Tsien, J.L. Meinkoth, S.S. Taylor, Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. Journal of Biological Chemistry. ,vol. 269, pp. 32214- 32220 ,(1994) , 10.1016/S0021-9258(18)31623-5
K. Nishi, M. Yoshida, D. Fujiwara, M. Nishikawa, S. Horinouchi, T. Beppu, Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. Journal of Biological Chemistry. ,vol. 269, pp. 6320- 6324 ,(1994) , 10.1016/S0021-9258(17)37374-X
Ingrid R. Vetter, Christine Nowak, Takeharu Nishimoto, Jürgen Kuhlmann, Alfred Wittinghofer, Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature. ,vol. 398, pp. 39- 46 ,(1999) , 10.1038/17969
Tanja la Cour, Ramneek Gupta, Kristoffer Rapacki, Karen Skriver, Flemming M Poulsen, Søren Brunak, NESbase version 1.0: a database of nuclear export signals Nucleic Acids Research. ,vol. 31, pp. 393- 396 ,(2003) , 10.1093/NAR/GKG101
Yuh Min Chook, Günter Blobel, Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature. ,vol. 399, pp. 230- 237 ,(1999) , 10.1038/20375
Connie Johnson, Daniel Van Antwerp, Thomas J Hope, An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα The EMBO Journal. ,vol. 18, pp. 6682- 6693 ,(1999) , 10.1093/EMBOJ/18.23.6682
Wei Wen, Judy L Meinkotht, Roger Y Tsien, Susan S Taylor, Identification of a signal for rapid export of proteins from the nucleus Cell. ,vol. 82, pp. 463- 473 ,(1995) , 10.1016/0092-8674(95)90435-2