Thrombolytic therapy for unstable angina.

摘要: Thrombolytic therapy for unsTable angina has not gained acceptance as a primary treatment (UA) despite the evidence showing reduction in mortality when these agents are given myocardial infarction. The purpose of this review is to examine clinical value thrombolytic UA. multiple lines supporting intracoronary thrombus formation key mechanism pathogenesis UA reviewed. Studies examining effect on angiographic endpoints have shown little extent luminal narrowing, but do reveal decrease angiographically detected thrombus. Twelve randomized, controlled trials 611 patients with predefined been published. These varied widely design and adjunctive both treated control groups. Review shows tendency fewer events such death, infarction, need revascularization patients, corresponding increase bleeding complications. Clinical efficacy cannot be excluded by available data, perhaps part because insufficient numbers treated. Determination net must await larger more definitive trials.